Hsv2 Vaccine Trials

Early results show that the vaccine is effective in reducing the recurrence of lesions and reducing viral sheddingthe first demonstration of reduced viral shedding by a therapeutic vaccine. Two experimental novel live-attenuated HSV-2 vaccine.

Vaccines Free Full Text Herpes Simplex Virus Type 2 Is More Difficult To Neutralize By Antibodies Than Herpes Simplex Virus Type 1 Html

March 13 2021 - The journal Vaccines published a study.

Hsv2 vaccine trials. The HSV529 Vaccine Trial Phase I randomized double-blind placebo-controlled study of replication-defective HSV-2 dl5-29 Healthy adult subjects 18-40 years of age with or without HSV. A phase 2 trial HSV-2 infected adults has been underway since September 2016 to evaluate the recurrence rates over a 12-month period following vaccination. Overall in the two experiments the mRNA vaccine prevented death and genital disease in 5454 100 mice infected with HSV-1 and 2020 100 with HSV-2 and prevented HSV DNA from reaching the dorsal root ganglia the site of virus latency in 2930 97 mice infected with HSV-1 and 1010 100 with HSV-2.

Assessment of Two Novel Live-Attenuated Vaccine Candidates for Herpes Simplex Virus 2 HSV-2 in Guinea Pigs. This therapeutic DNA vaccine for individuals with HSV-2 is also in ongoing phase II trials. 9 rows The primary objectives of the study are.

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